IgE antibodies are found primarily in mucous secretions. In serum it is present in very low concentrations and elevated in atopic diseases such as allergic asthma, hay fever and atopic dermatitis. An IgE reaction occurs about the time immediately after exposure to the allergen; food or inhalant. This type of reaction is referred to as a Type I immediate hypersensitivity reaction. IgE antibodies that are specific for the allergen, bind onto immune cells called mast cells and basophils. The allergen latches onto the mast cell-bound IgE antibodies in a cross-linking manner. This initiates the release of histamine and other inflammatory mediators from these cells. The allergic IgE response is comprised of not only an immediate event but in many cases, a late event as well. The early phase reaction usually occurs within 15 minutes of exposure to the allergen. The late phase reaction may then occur 4-6 hours later and persist for days with increased edema and inflammation.
16 Vegetarian Food (item add-on)
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