Organic Acids Profile

Vitamin deficiencies and imbalances may produce a range of health issues, including fatigue, mood changes, digestive problems, and others. Our Organic Acids Profile measures 36 organic acids to create a unique patient biochemistry profile that reflects how well the body is obtaining and utilizing nutrients. A customized diet and lifestyle plan can then be established to address specific nutritional needs.


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36 Organic Acids are analyzed to indicate key markers of metabolic health:

Glycolysis Metabolites

  • Pyruvate
  • Lactate

Citric Acid Cycle Metabolites

  • Citrate
  • Cis-Aconitate
  • Isocitrate
  • Alpha-Ketoglutarate
  • Succinate
  • Fumarate
  • Malate

Fatty Acid Oxidation

  • Adipate
  • Suberate
  • Ethylmalonate
  • Methylsuccinate

Ketone Metabolites

  • Beta-Hydroxybutyrate

Markers for Cofactor Need

  • Alpha-Ketoisovalerate
  • Alpha-Ketoisocaproate
  • Alpha-Keto-Beta-Methylvalerate
  • Beta-Hydroxyisovalerate
  • Methylmalonate
  • Kynurenate
  • Hydroxymethylglutarate

Markers of Neurotransmitter Metabolism

  • Vanilmandelate
  • Homovanillate
  • 5-Hydroxyindoleacetate
  • Quinolinate

Markers of Detoxification

  • Para-Hydroxyphenyllactate
  • Orotate
  • Alpha-Hydroxybutyrate
  • Pyroglutamate
  • Benzoate
  • Hippurate

Markers of Bacterial Metabolism

  • Para-Hydroxybenzoate
  • Para-Hydroxyphenylacetate
  • 2-Hydroxyphenylacetate
  • 3-Indoleacetate
  • Tricarballylate

Testing Process

Liquid Chromatography/ Triple Quadrupole Mass Spectrometry (LC-MS/MS) instrumentation is used to quantitatively evaluate patient urine specimens for metabolically-derived organic acids and evidence of exposure to environmental pollutants. Our Urinary Metabolic Profile is run on this comprehensive testing platform, which offers superb separation, resolution, and identification of compounds from a complex biological mixture such as urine, yielding precise and repeatable results.

More information on LC-MS/MS

Sample Report

See a Sample Report of the Organic Acids Profile here.

Specimen Requirements

The Organic Acids Profile requires a dried urine sample, easily collected via our simple urine collection card.

Dried Urine Collection Instructions