Amenorrhoea is a complex presentation requiring careful differentiation of underlying drivers. Static serum measures often miss the multifactorial influences shaping menstrual disruption. This seminar centres on the EndoInsight dried-urine profile—a single, at-home collection that reveals endocrine rhythms and functional biochemistry critical for guiding diagnosis and care.
We will examine the case of a woman with amenorrhoea whose EndoInsight results demonstrated a high environmental toxin burden, disrupting ovarian and endocrine function. This case illustrates how targeted functional testing can identify hidden barriers, explain hormone suppression, and direct appropriate management within reproductive endocrinology.
- Identify deviations in the sex-steroid axis (oestrogens, progesterone metabolites, androgens) and stress–sleep axis (cortisol/cortisone and melatonin) that underpin amenorrhoea.
- Link toxin-related endocrine disruption to clinical features such as absent menses, mood disturbance, metabolic change, and reproductive compromise.
- Integrate broader biomarkers—environmental toxins, heavy-metal burden, and key organic acids—into the differential diagnosis.
- Translate complex EndoInsight hormone data data into an integrative treatment pathway, combining toxin clearance, hormonal support, and personalised lifestyle interventions.
