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July 2009
According to a recent Mayo Clinic study, published in this month’s journal of Gastroenterology, July 2009, the prevalence of undiagnosed celiac disease (CD) is 4 times more common today than it was 50 years ago. This finding was shown by testing a unique collection of frozen sera from 9,133 healthy young adults at Warren Air Force Base, WAFB cohort (sera were collected between 1948 and 1954), and comparing serological values for tissue transglutaminase and endomysial antibodies against two present-day age and gender-matched cohorts.
In this large historical cohort, during 45 years of follow-up, undiagnosed CD was associated with a nearly 4-fold increased risk of death compared to subjects without serological evidence of CD.
The research group suggests that the most likely explanation for these findings is changes in industry processing of cereal. That is, changes in wheat genetics, bread processing, and enzymatic modification of wheat prolamins, that have occurred in the past 40 years. And, because human genetic changes are slow in response to environmental challenges – we have not adapted fast enough.
The abstract to this paper may be found at the references:
http://www.ncbi.nlm.nih.gov/ - Increased prevalence and mortality in undiagnosed celiac disease
http://www.ncbi.nlm.nih.gov/ - Rubio-Tapia A, Kyle RA, Kaplan EL, Johnson DR, Page W, Erdtmann F, Brantner TL, Kim WR, Phelps TK, Lahr BD, Zinsmeister AR, Melton LJ 3rd, Murray JA.
http://www.ncbi.nlm.nih.gov/ - Gastroenterology.
2009 Jul; 137(1):88-93.
Further information on CD is available from the CDC Consensus Conference on Celiac Disease. This report can be downloaded from CDC's website using the following link:
http://consensus.nih.gov/2004/2004CeliacDisease118main.htm - NIH Consensus Development Conference on Celiac Disease.
US BioTek’s Celiac Antibody Panel.
Available for Serum or Whole Blood Specimens through Finger Stick.
To view complete test panel information please click here.
A brief overview of CD may be found in BioTeknology, Volume 7 (Spring 2008).
US BioTek Laboratories has set a new standard for identifying and quantifying both serum IgA, IgE and IgG antibodies in response to Foods, Inhalants, Spices, and Herbs.
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