Urinary Metabolic Profile - Test Overview

Test Description:

A quantitative GC/MS analysis for the assessment of organic acids in urine.

Analytes:

Glycolysis Metabolites: Pyruvate, Lactate

Citric Acid Cycle Metabolites:

Citrate, Cis-Aconitate, Isocitrate, Alpha- Ketoglutarate, Succinate, Fumarate, Malate

Fatty Acid Oxidation & Ketone Metabolites:

Adipate, Suberate, Ethylmalonate, Methylsuccinate, Alpha-Hydroxybutyrate, Beta-Hydroxybutyrate

Markers of Cofactor Need:

Alpha-Ketoisovalerate,

Alpha-Ketoisocaproate, Alpha-Keto-Beta-Methylvalerate,

Methylmalonate, Beta-Hydroxyisovalerate, Kynurenate,

Hydroxymethylglutarate

Markers of Neurotransmitter Metabolism:

Vanilmandelate, Homovanillate, 5-Hydroxyindoleacetate, Quinolinate

Markers of Detoxification & Bacterial Origin:

Para-Hydroxyphenyllactate,

Orotate, Pyroglutamate, Para-Hydroxybenzoate,

Para-Hydroxyphenylacetate, 3-Indoleacetate,

2-ydroxyphenylacetate, Benzoate, Hippurate, Tricarballylate

CPT Codes:

Pyruvate (84210)

Lactate (83605)

Citrate (82507)

Vanilmandelate (84585)

5-Hydroxyindoleacetate (83497)

Homovanillate (83150)

All other Organic Acids (83921)

RT = Room Temperature 21°C-26°C

Causes for Rejection:

Specimen collected on an expired kit or specimen that has not been sealed securely in the top lock bag, containing desiccant provided. These may result in a damp specimen on arrival. Overly dilute urine sample may result in a low creatinine value. This may render test results non-reportable.

Interfering Substances:

See food list below.

Supplements and medications may alter test results. Unless specified by the ordering physician, it is suggested to avoid all supplements and medications for 48 hours prior to urine collection.

Antidepressant medications such as Monoamine Oxidase Inhibitors (MAOIs), Tricyclic Antidepressants (TCA), and Selective Serotonin Re-uptake Inhibitors (SSRIs), including medications used to treat Parkinson’s.

Test Run Time:

5-10 business days from receipt of specimen.

Special Collection Instructions:

*Avoid excess fluid intake after evening meal*

Questions regarding diet & allergy are directed towards the healthcare provider

* Benzoic Acid (Benzoate) & Sorbic Acid (Sorbate) are avoided for the Environmental Pollutants Test

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