High Sensitivity CRP (hs-CRP)
Serum, Finger Stick
Originally named for its ability to react with C-polysaccharide of Streptococcus pneumoniae, C-Reactive Protein, CRP, is a protein produced by the liver, the circulating concentration of which rises acutely and rapidly in a cytokine-mediated response to most forms of tissue injury, infection and inflammation. CRP may activate the classical complement pathway and stimulate tissue-factor production; a key protein involved in blood coagulation. This in turn may contribute to the pathogenesis of coronary heart disease over time at CRP levels that were previously considered normal.
Measurement of CRP by a high sensitivity assay, hs-CRP, allows for a lower detection limit related to chronic, low grade inflammation which is associated with heart disease. Hs-CRP may add to the predicative value of other markers used to assess a patient's risk of heart and peripheral vascular disease.
RISK FACTORS FOR HEART DISEASE
| MODIFIABLE |
NONMODIFIABLE |
Smoking or exposure to environmental tobacco smoke |
Male sex |
Obesity |
Age older than 50 years |
Sedentary lifestyle |
Family history of heart disease |
Diabetes |
Post-menopausal |
High cholesterol or abnormal blood lipids |
Race (African Americans, American Indians, Mexican Americans) |
Hypertension |
|
Poorly controlled stress and anger |
|
High CRP |
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Diet (sodium, saturated fat, trans fat, cholesterol, refined sugar) |
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CRP remains a general nonspecific marker of inflammation in the body and test values should not be interpreted in the absence of a complete clinical history. In addition to injury and infection, elevated levels may occur for other reasons including :
Burns
Recent major surgery
Autoimmune condition (Rheumatoid Arthritis, Lupus)
Long-term disease (Cancer)
CRP may be used to monitor treatment measures for the inflammatory condition once identified.
CRP test is not advised for the individual on chronic steroid medication use. NSAIDS, or nonsteroidal anti-inflammatory drugs (eg: Aspirin, Advil, Motrin, Naproxin) or statins may reduce serum CRP levels. Consult your health care practitioner before making any changes to your current medication regime.
The test is not suitable for ages 3 years and below.
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